Abstract for: Dynamic Modelling of Circadian Rhythm Disorder and its Connections to Autism in Fetus

Autism is a neuropsychiatric disorder that is globally being diagnosed at increasing rates. The circadian rhythm or biological clock is a cyclical process in living organisms by which hormones are secreted and suppressed at certain hours of the day, depending on the light. Disruption of the circadian rhythm causes an increase in oxidative stress and a decrease in melatonin levels, especially in the fetus. Many studies have been conducted on the possibility that these changes may cause neuropsychological disorders in the fetus, including autism. This study aims to examine the dynamics of the circadian rhythm in a pregnant woman using a systems dynamics methodology, focusing on its interactions with the fetus. To this end, three body subsystems in interactions will be modeled: endocrine, nervous, and immune. It is known that the circadian rhythm significantly influences the dynamics of these subsystems. The long-term goal of this study is the discovery of early diagnosis or treatment options that may prevent autism development due to circadian rhythm disruption in the fetus.