Abstract for: A Dynamic Simulation Model for Insulin Resistance and Type II Diabetes in the Context of Obesity
Type II diabetes, is a common endocrinological disease leading to other serious health problems such as heart disease, kidney dysfunction that may eventually lead to a premature death. Insulin resistance is seen as the starting point of this disorder. Obesity, hyperglycemia and hyperinsulinemia are the main reasons for insulin resistance and type II diabetes. The aim of this study is to construct a dynamic simulation model that can realistically reproduce the long term behavior of developing insulin resistance and type II diabetes related to obesity. Thus a model is constructed which focuses on the interaction between body weight of an average individual and glucose-insulin regulation. According to the available research, doing exercise and changes in diet may reduce the severity of insulin resistance or even eliminate this disorder completely. Simulation experiments show that different exercise levels and dietary intakes have impact on the insulin resistance development. In the long run, insulin secretion and beta-cell dysfunctionality play a more significant role in developing type II diabetes. In conclusion, the significance of obesity effect on insulin resistance and type II diabetes is demonstrated by simulation experiments, supported by available information and data in the literature.