As part of an integrated system, healthcare infrastructure should be planned and evaluated in conjunction with the services it supports. However, this is challenging because of uncertainty about future requirements due to technological, demographic, medical and policy change. Long lasting infrastructure needs to support healthcare processes that change rapidly. In the UK public private partnership models provide additional challenges for the National Heath Service. Contractual agreements between public sector providers of care services and the organisations responsible for the provision and maintenance of the built infrastructure typically last 30 years or more. Over this period both the demands for care services and the technologies used to deliver them are likely to change considerably. Infrastructure needs to be able to adapt to these changes, and planning tools need to recognise the interdependencies within the care service and care infrastructure system. System dynamics modelling offers the potential to plan for these challenges. It can help to guide the planning process of new healthcare infrastructure under conditions of uncertainty, so that the services it enables can meet present and future needs. The stylised model presented considers care service delivery over time depending on infrastructure flexibility options (e.g. to increase capacity) under different scenarios.