The current avian influenza in Asia, Africa, and Europe has sparked discussions of a new human pandemic influenza perhaps hitting the world. While the current influenza is not spread by human-to-human contact—a necessary characteristic for a human pandemic—there is a potential that it may become so. Since the pandemic does not currently exist, it is not known what characteristics—such as infectiousness and death rate—the disease will exhibit. The study conducted by the Critical Infrastructure Protection Decision Support System (CIPDSS) explores the possible mitigation strategies and their effect on the US economy. Results show that while many people may be infected, the economic costs for the US are relatively low compared to past economic perturbations.