Growing interest in serial killers topic we face started two years ago by two cases that shake up public view of this phenomenon in Czech Republic. Serial killer behavior used to be very rare in the country. The only contact of the society was an old case from 50´s and later just the Hollywood production represented by the “Silence of the lambs” movie. Two cases in two years raised both expert and public discussion only to discover that there are mostly emotions on the side of public and non-acquaintance on the side of professionals. A forensic psychiatry chapter of the Purkyne’s Medical Society declared interest in dynamic models of the serial homicide behavior (psychobiological and-or psychosocial) and this paper describes the process of its construction.