The rapid spread of HIV/AIDS is a global crisis one that is particularly devastating to the economies of nations where the disease is most prevalent. Booz Allen Hamilton, in conjunction with the Global Business Coalition on HIV/AIDS (GBC) and the Confederation of Indian Industry (CII), developed an innovative approach for The AIDS Epidemic in India: A Strategic Simulation. Their approach captures the complex interdependencies that drive the HIV/AIDS epidemic and its economic consequences. At the core of this strategic simulation is an analytic framework that leverages epidemiological and economic System Dynamics modeling, partnerships with leading academic centers, and simulation-driven gaming.