Hsinchu Science Park is an example of hi-technology industry development in Taiwan. Its rapid growth has brought tremendous economic benefits, though not without social and environmental impacts, resulting in conflict between economic growth and sustainable development of the science city. This study establishes a system dynamic model using STELLA programming language to simulate different development scenarios of Hsinchu Science City. Our analysis reveals that the development of the science city should comply with the objectives of (1) maximizing the profits from industries in the science park, (2) minimizing the damages incurred by the science park on its mother city, (3) decrease in consumption of natural resources, (4) reduction in environmental pollution, and (5) attention to relevant social problems.